Transposition-Driven Genomic Heterogeneity in the Drosophila Brain-Reference-Cited by-同舟云学术

Transposition-Driven Genomic Heterogeneity in the Drosophila Brain

Published:2013-04-05 Issue:6128 Volume:340 Page:91-95
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Perrat Paola N.¹,DasGupta Shamik¹²,Wang Jie³,Theurkauf William⁴,Weng Zhiping³,Rosbash Michael⁵,Waddell Scott¹²

Affiliation:

1. Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

2. Center for Neural Circuits and Behaviour, University of Oxford, Oxford OX1 3TA, UK.

3. Program in Bioinformatics and Integrative Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.

4. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.

5. Howard Hughes Medical Institute and National Center for Behavioral Genomics, Department of Biology, Brandeis University, Waltham, MA 02454, USA.

Abstract

Neuronal Transposons Transposons comprise a hefty chunk of the Drosophila genome and, unregulated, can generate mutations; thus, mechanisms exist to suppress transposon activity, particularly in the germline. Perrat et al. (p. 91 ) investigated transposon motility in neurons of the Drosophila brain. The mushroom body of the brain, responsible for olfactory memory, contains several different types of neurons. One class of neurons, the αβ neurons, exhibited increased transposon mobility, which generated increased neuronal diversity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference49 articles.

1. The impact of retrotransposons on human genome evolution

2. Mobile Elements: Drivers of Genome Evolution

3. J. S. Kaminker et al . Genome Biol. 3 RESEARCH0084 (2002).

4. L1 retrotransposition in human neural progenitor cells

5. Somatic retrotransposition alters the genetic landscape of the human brain

Cited by 203 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Short communication: Differential expression of piwi1 and piwi2 genes in tissues of tambacu and zebrafish: A possible relationship with the indeterminate muscle growth;Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology;2024-11

2. The role of transposable elements in long-term memory formation;Генетика;2024-09-11

3. A hypothesis about interrelations of epigenetic factors and transposable elements in memory formation;Vavilov Journal of Genetics and Breeding;2024-09-02

4. The Ecology of Transposable Elements;Transposable Elements and Genome Evolution;2024-08-16

5. Retrotransposons in embryogenesis and neurodevelopment;Biochemical Society Transactions;2024-05-08