Role of Inorganic Polyphosphate in Promoting Ribosomal Protein Degradation by the Lon Protease in E. coli-Reference-Cited by-同舟云学术

Role of Inorganic Polyphosphate in Promoting Ribosomal Protein Degradation by the Lon Protease in E. coli

Published:2001-07-27 Issue:5530 Volume:293 Page:705-708
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kuroda Akio¹,Nomura Kazutaka¹,Ohtomo Ryo²,Kato Junichi¹,Ikeda Tsukasa¹,Takiguchi Noboru¹,Ohtake Hisao¹,Kornberg Arthur²

Affiliation:

1. Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, 1-4-1 Kagamiyama, Hiroshima 739-8527, Japan.

2. Department of Biochemistry, Stanford University, Stanford, CA 94305–5307, USA.

Abstract

Inorganic polyphosphate (polyP), a polymer of hundreds of phosphate (P i ) residues, accumulates in Escherichia coli in response to stresses, including amino acid starvation. Here we show that the adenosine 5′-triphosphate–dependent protease Lon formed a complex with polyP and degraded most of the ribosomal proteins, including S2, L9, and L13. Purified S2 also bound to polyP and formed a complex with Lon in the presence of polyP. Thus, polyP may promote ribosomal protein degradation by the Lon protease, thereby supplying the amino acids needed to respond to starvation.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

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