Antimicrobial peptides: Application informed by evolution-Reference-Cited by-同舟云学术

Antimicrobial peptides: Application informed by evolution

Published:2020-05 Issue:6490 Volume:368 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Lazzaro Brian P.¹^ORCID,Zasloff Michael²,Rolff Jens³⁴^ORCID

Affiliation:

1. Department of Entomology, Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, NY, USA.

2. MedStar Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, USA.

3. Freie Universität Berlin, Evolutionary Biology, Institut für Biologie, Königin-Luise-Strasse 1-3, 14195 Berlin, Germany.

4. Berlin-Brandenburg Institute of Advanced Biodiversity Research (BBIB), 14195 Berlin, Germany.

Abstract

Small-molecule defense Small-peptide defense molecules are produced by most organisms to fend off invasion by bacteria. The antimicrobial peptides that we know about so far show substantial diversity, synergism, and alternative functions. Lazzaro et al. review our knowledge of the evolution and diversity of antimicrobial peptides, the rapid pharmacodynamics of which make them promising candidates for translational applications to complement efforts to overcome antibiotic resistance. Science , this issue p. eaau5480

Funder

NIH Office of the Director

H2020 European Research Council

Deutsche Forschungsgemeinschaft

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference100 articles.

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