Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators-Reference-Cited by-全球学者库

Convergence of Transforming Growth Factor-β and Vitamin D Signaling Pathways on SMAD Transcriptional Coactivators

Published:1999-02-26 Issue:5406 Volume:283 Page:1317-1321
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yanagisawa Junn¹,Yanagi Yasuo¹,Masuhiro Yoshikazu¹,Suzawa Miyuki¹²,Watanabe Michiko¹,Kashiwagi Kouji¹,Toriyabe Takeshi¹,Kawabata Masahiro³,Miyazono Kohei³,Kato Shigeaki¹²

Affiliation:

1. Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.

2. CREST, Japan Science and Technology, 4-1-8 Honcho, Kawaguchi, Saitama 332, Japan.

3. Department of Biochemistry, The Cancer Institute, Tokyo, Japanese Foundation for Cancer Research (JFCR), and Research for the Future Program, Japan Society for the Promotion of Science, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan.

Abstract

Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor–β (TGF-β) and the liphophilic hormone vitamin D. TGF-β causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-β signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator–1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-β signaling pathways.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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