Affiliation:
1. Basel Institute for Immunology, Grenzacherstrasse 487, CH 4005 Basel, Switzerland.
Abstract
Although dispensable, costimulation through CD28 facilitates activation of naı̈ve T lymphocytes. CD28 engagement led to the redistribution and clustering of membrane and intracellular kinase-rich raft microdomains at the site of T cell receptor (TCR) engagements. Although not affecting TCR down-regulation, this process led to higher and more stable tyrosine phosphorylation of several substrates and higher consumption of Lck. These results may provide a general mechanism for amplifying receptor signaling by reorganization of membrane microdomains.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
860 articles.
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