RIGorous Detection: Exposing Virus Through RNA Sensing-Reference-Cited by-同舟云学术

RIGorous Detection: Exposing Virus Through RNA Sensing

Published:2010-01-15 Issue:5963 Volume:327 Page:284-286
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rehwinkel Jan¹,Reis e Sousa Caetano¹

Affiliation:

1. Immunobiology Laboratory, Cancer Research UK (CRUK) London Research Institute, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK.

Abstract

Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I–like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference20 articles.

1. Innate Recognition of Viruses

2. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production

3. Pathogenesis of emerging avian influenza viruses in mammals and the host innate immune response

4. RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

5. 5'-Triphosphate RNA Is the Ligand for RIG-I

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