Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs-Reference-Cited by-全球学者库

Infectivity, Transmission, and Pathology of Human-Isolated H7N9 Influenza Virus in Ferrets and Pigs

Published:2013-07-12 Issue:6142 Volume:341 Page:183-186
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhu H.¹²³,Wang D.⁴,Kelvin D. J.⁵⁶⁷,Li L.¹,Zheng Z.¹,Yoon S.-W.⁸,Wong S.-S.⁸,Farooqui A.⁵,Wang J.¹³,Banner D.⁶,Chen R.¹,Zheng R.¹,Zhou J.¹²³,Zhang Y.¹,Hong W.¹,Dong W.⁵,Cai Q.¹,Roehrl M. H. A.⁶⁷,Huang S. S. H.⁶⁷,Kelvin A. A.⁵⁶,Yao T.¹,Zhou B.²,Chen X.²,Leung G. M.³,Poon L. L. M.²³,Webster R. G.⁸,Webby R. J.⁸,Peiris J. S. M.²³,Guan Y.¹²³,Shu Y.⁴

Affiliation:

1. Joint Influenza Research Centre [Shantou University Medical College (SUMC)/University of Hong Kong (HKU)], Shantou University, Shantou, PR China.

2. State Key Laboratory of Emerging Infectious Diseases (HKU-Shenzhen Branch), Shenzhen Third People’s Hospital, Shenzhen, PR China.

3. State Key Laboratory of Emerging Infectious Diseases/Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong SAR, PR China.

4. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, PR China.

5. Joint Vaccine Research Centre [SUMC/University Health Network (UHN)], Shantou University Medical College, Shantou, PR China.

6. University Health Network, Toronto, Ontario, Canada.

7. University of Toronto, Toronto, Ontario, Canada.

8. Division of Virology, Department of Infectious Diseases, St. Jude Children’s Research Hospital, Memphis, TN, USA.

Abstract

Avian Flu in Ferrets A recent outbreak of avian H7N9 influenza in humans in eastern China has been closely monitored for any evidence of human-to-human transmission and its potential for sparking a pandemic. Zhu et al. (p. 183 , published online 23 May) examined the behavior of the avian virus in the ferret, a mammalian model for human influenza. The virus was excreted by the ferrets and could be transmitted readily by contact but displayed limited capacity for airborne infectivity. The pathology of H7N9 is similar to H1N1, and it seems that factors other than the intrinsic pathogenicity of the virus contribute to the reported high fatality rate.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference21 articles.

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