From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes-Reference-Cited by-同舟云学术

From Knowing to Controlling: A Path from Genomics to Drugs Using Small Molecule Probes

Published:2003-04-11 Issue:5617 Volume:300 Page:294-295
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Strausberg Robert L.¹,Schreiber Stuart L.²

Affiliation:

1. Cancer Genomics Office, National Cancer Institute, 31 Center Drive, Bethesda, MD 20892, USA.

2. Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02115, USA.

Abstract

The National Cancer Institute Initiative in Chemical Genetics is designed to encourage the development of small molecular probes. The probes are useful for activating or inactivating protein functions, thereby providing resources that help discern the functions of gene products in normal and disease cells, as well as in tissues. This initiative includes “ChemBank,” a suite of informatics tools and databases aimed at promoting the development and use of chemical genetics by scientists worldwide. The information generated with such tools should provide a critical link from genomic discovery to drug development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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1. Genome and genetic resources from the Cancer Genome Anatomy Project

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4. See .

5. Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen

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