The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice-Reference-Cited by-同舟云学术

The Growth Factor Progranulin Binds to TNF Receptors and Is Therapeutic Against Inflammatory Arthritis in Mice

Published:2011-04-22 Issue:6028 Volume:332 Page:478-484
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tang Wei¹²,Lu Yi¹²,Tian Qing-Yun¹,Zhang Yan¹,Guo Feng-Jin¹,Liu Guang-Yi¹,Syed Nabeel Muzaffar¹,Lai Yongjie¹,Lin Edward Alan¹,Kong Li¹,Su Jeffrey³,Yin Fangfang⁴,Ding Ai-Hao⁴,Zanin-Zhorov Alexandra⁵,Dustin Michael L.⁵,Tao Jian⁶,Craft Joseph⁶,Yin Zhinan⁷,Feng Jian Q.⁸,Abramson Steven B.⁹,Yu Xiu-Ping²,Liu Chuan-ju¹¹⁰

Affiliation:

1. Department of Orthopaedic Surgery, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.

2. Institute of Pathogenic Biology, Shandong University School of Medicine, Jinan, Shandong 250012, China.

3. Cytovance Biologics, Oklahoma City, OK 73104, USA.

4. Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, NY 10065, USA.

5. Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.

6. Section of Rheumatology, Department of Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

7. College of Life Sciences, Nankai University, Tianjin 300071, China.

8. Baylor College of Dentistry, Texas A&M Health Science Center, Dallas, TX 75246, USA.

9. Division of Rheumatology, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.

10. Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

Abstract

A growth factor protects against arthritis in mice by blocking tumor necrosis factor–dependent signaling.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

http://www.sciencemag.org/content/332/6028/478.full.pdf

Reference35 articles.

1. The hairpin stack fold, a novel protein architecture for a new family of protein growth factors

2. The granulin gene family: from cancer to dementia

3. Granulin epithelin precursor: a bone morphogenic protein 2‐inducible growth factor that activates Erk1/2 signaling and JunB transcription factor in chondrogenesis

4. Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumorigenesis

5. Cellular Localization of Gene Expression for Progranulin

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