mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate-Reference-Cited by-同舟云学术

mTORC1 activity repression by late endosomal phosphatidylinositol 3,4-bisphosphate

Published:2017-06-02 Issue:6341 Volume:356 Page:968-972
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Marat Andrea L.¹^ORCID,Wallroth Alexander¹^ORCID,Lo Wen-Ting¹^ORCID,Müller Rainer²^ORCID,Norata Giuseppe Danilo³⁴,Falasca Marco⁴^ORCID,Schultz Carsten²,Haucke Volker¹^ORCID

Affiliation:

1. Leibniz-Forschungsinstitut für Molekulare Pharmakologie, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.

2. European Molecular Biology Laboratory, Cell Biology and Biophysics Unit, 69117 Heidelberg, Germany.

3. Department of Pharmacological and Biomolecular Sciences, University of Milan, 20133 Milan, Italy.

4. Curtin Health Innovation Research Institute, School of Biomedical Sciences, Curtin University, Perth, Western Australia, Australia.

Abstract

Effects of a lipid signaling molecule depend on its subcellular location.

Funder

Banting Research Foundation

Deutsche Forschungsgemeinschaft

Alexander von Humboldt Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. SnapShot: mTORC1 Signaling at the Lysosomal Surface

2. Making new contacts: the mTOR network in metabolism and signalling crosstalk

3. PI3K signalling: the path to discovery and understanding

4. Lipid signalling in disease

5. Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

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