Extensive migration of young neurons into the infant human frontal lobe-Reference-Cited by-同舟云学术

Extensive migration of young neurons into the infant human frontal lobe

Published:2016-10-07 Issue:6308 Volume:354 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Paredes Mercedes F.¹²,James David¹³,Gil-Perotin Sara⁴⁵,Kim Hosung⁶,Cotter Jennifer A.⁷,Ng Carissa¹³,Sandoval Kadellyn¹²,Rowitch David H.¹⁸⁹,Xu Duan⁶,McQuillen Patrick S.⁸,Garcia-Verdugo Jose-Manuel⁴,Huang Eric J.¹⁶⁷,Alvarez-Buylla Arturo¹³

Affiliation:

1. Edythe Broad Institute for Stem Cell Research and Regeneration Medicine, University of California, San Francisco, CA 94143, USA.

2. Department of Neurology, University of California, San Francisco, CA 94143, USA.

3. Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA.

4. Laboratory of Comparative Neurobiology, Instituto Cavanilles, Universidad de Valencia, CIBERNED, Valencia, Spain.

5. Multiple Sclerosis and Neural Regeneration Unit, Department of Neurology, Hospital Universitario y Politecnico La Fe, 46026 Valencia, Spain.

6. Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94143, USA.

7. Department of Pathology, University of California, San Francisco, CA 94143, USA.

8. Department of Pediatrics, University of California, San Francisco, CA 94143, USA.

9. Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

Abstract

Building the human brain As the brain develops, neurons migrate from zones of proliferation to their final locations, where they begin to build circuits. Paredes et al. have discovered that shortly after birth, a group of neurons that proliferates near the ventricles migrates in chains alongside circulatory vessels into the frontal lobes (see the Perspective by McKenzie and Fishell). Young neurons that migrate postnatally into the anterior cingulate cortex then develop features of inhibitory interneurons. The number of migratory cells decreases over the first 7 months of life, and by 2 years of age, migratory cells are not evident. Any damage during migration, such as hypoxia, may affect the child's subsequent physical and behavioral development. Science , this issue p. 81 ; see also p. 38

Funder

California Institute of Regenerative Medicine

NIH

Spanish Institute of Health Carlos III

Rio Hortega fellowship

Banting and FRS Canadian fellowships

Economics and Competitivity Ministry of Spain

Generalitat Valenciana

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary