Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus-Reference-Cited by-同舟云学术

Structural Basis of Preexisting Immunity to the 2009 H1N1 Pandemic Influenza Virus

Published:2010-04-16 Issue:5976 Volume:328 Page:357-360
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Xu Rui¹,Ekiert Damian C.¹,Krause Jens C.²,Hai Rong³,Crowe James E.²,Wilson Ian A.¹⁴

Affiliation:

1. Department of Molecular Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2. Departments of Pediatrics and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

3. Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA.

4. Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

Swine Flu Neutralized The 2009 H1N1 flu virus had an unusually low infection rate in elderly people. An antibody isolated from survivors of the 1918 flu pandemic was recently shown to cross-neutralize 2009 H1N1 viruses. Xu et al. (p. 357 , published online 25 March) report crystal structures of the virus envelope protein, hemagglutinin (HA) from 2009 H1N1 and of 1918 H1 HA in complex with a neutralizing antibody that cross-reacts with both pandemic viruses. These studies reveal an epitope that is conserved in the pandemic viruses, but divergent in other known H1 HAs, from the 1930s to the present. This antigenic similarity explains the age-related immunity to the 2009 H1N1 influenza.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. Influenza: old and new threats

2. World Health Organization www.who.int.

3. Receptor Binding and Membrane Fusion in Virus Entry: The Influenza Hemagglutinin

4. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic

5. Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

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