Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26-Reference-Cited by-全球学者库

Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26

Published:2004-08-13 Issue:5686 Volume:305 Page:1000-1003
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Christopherson Kent W.¹²,Hangoc Giao¹²,Mantel Charlie R.¹²,Broxmeyer Hal E.¹²

Affiliation:

1. Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

2. Walther Cancer Institute, Indianapolis, IN 46208, USA.

Abstract

Hematopoietic stem cell homing and engraftment are crucial to transplantation efficiency, and clinical engraftment is severely compromised when donor-cell numbers are limiting. The peptidase CD26 (DPPIV/dipeptidylpeptidase IV) removes dipeptides from the amino terminus of proteins. We present evidence that endogenous CD26 expression on donor cells negatively regulates homing and engraftment. By inhibition or deletion of CD26, it was possible to increase greatly the efficiency of transplantation. These results suggest that hematopoietic stem cell engraftment is not absolute, as previously suggested, and indicate that improvement of bone marrow transplant efficiency may be possible in the clinic.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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