Cell Migration: Integrating Signals from Front to Back-Reference-Cited by-同舟云学术

Cell Migration: Integrating Signals from Front to Back

Published:2003-12-05 Issue:5651 Volume:302 Page:1704-1709
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Ridley Anne J.¹²³⁴⁵,Schwartz Martin A.¹²³⁴⁵,Burridge Keith¹²³⁴⁵,Firtel Richard A.¹²³⁴⁵,Ginsberg Mark H.¹²³⁴⁵,Borisy Gary¹²³⁴⁵,Parsons J. Thomas¹²³⁴⁵,Horwitz Alan Rick¹²³⁴⁵

Affiliation:

1. Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.

2. Departments of Microbiology and Biomedical Engineering, Cardiovascular Research Center and Mellon Prostate Cancer Research Institute; University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

3. Department of Microbiology; University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

4. Department of Cell Biology; University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

5. Department of Cell and Developmental Biology and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Abstract

Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference59 articles.

1. Developmental Biology 2003

2. Robbins Pathologic Basis of Disease 1999

3. Cell Migration: A Physically Integrated Molecular Process

4. B. Knight et al., Curr. Biol.10, 576 (2000).

5. P. Friedl, K. Wolf, Nature Rev. Cancer3, 362 (2003).

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