Reduced grid-cell–like representations in adults at genetic risk for Alzheimer’s disease

Abstract

Early signs of dementia There is currently no cure for Alzheimer's disease. One of the reasons could be that interventions start too late, when there is already irreversible damage to the brain. Developing a biomarker that would help to effectively start therapy at very early stages of the disease is thus of high interest. Kunz et al. studied neural correlates of spatial navigation in the entorhinal cortex in control study participants and individuals at risk of developing Alzheimer's. The at-risk group showed a different brain signal many decades before the onset of the disease, and they navigated differently in a virtual environment. Science , this issue p. 430