Yolk sac cell atlas reveals multiorgan functions during human early development-Reference-Cited by-同舟云学术

Yolk sac cell atlas reveals multiorgan functions during human early development

Published:2023-08-18 Issue:6659 Volume:381 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Goh Issac¹²^ORCID,Botting Rachel A.¹²^ORCID,Rose Antony¹²^ORCID,Webb Simone¹²^ORCID,Engelbert Justin²^ORCID,Gitton Yorick³^ORCID,Stephenson Emily¹²^ORCID,Quiroga Londoño Mariana⁴^ORCID,Mather Michael²,Mende Nicole⁴^ORCID,Imaz-Rosshandler Ivan⁴⁵^ORCID,Yang Lu¹^ORCID,Horsfall Dave¹²^ORCID,Basurto-Lozada Daniela¹²^ORCID,Chipampe Nana-Jane¹^ORCID,Rook Victoria¹,Lee Jimmy Tsz Hang¹^ORCID,Ton Mai-Linh⁴^ORCID,Keitley Daniel¹⁶^ORCID,Mazin Pavel¹^ORCID,Vijayabaskar M. S.⁴^ORCID,Hannah Rebecca⁴^ORCID,Gambardella Laure¹^ORCID,Green Kile⁷^ORCID,Ballereau Stephane¹,Inoue Megumi³^ORCID,Tuck Elizabeth¹^ORCID,Lorenzi Valentina¹^ORCID,Kwakwa Kwasi¹,Alsinet Clara¹⁸^ORCID,Olabi Bayanne¹²,Miah Mohi¹²^ORCID,Admane Chloe¹²,Popescu Dorin-Mirel²,Acres Meghan²,Dixon David²^ORCID,Ness Thomas⁹^ORCID,Coulthard Rowen⁹,Lisgo Steven²^ORCID,Henderson Deborah J.²^ORCID,Dann Emma¹^ORCID,Suo Chenqu¹^ORCID,Kinston Sarah J.⁴^ORCID,Park Jong-eun¹⁰^ORCID,Polanski Krzysztof¹^ORCID,Marioni John¹¹¹¹²^ORCID,van Dongen Stijn¹,Meyer Kerstin B.¹^ORCID,de Bruijn Marella¹³,Palis James¹⁴^ORCID,Behjati Sam¹¹⁵^ORCID,Laurenti Elisa⁴^ORCID,Wilson Nicola K.⁴^ORCID,Vento-Tormo Roser¹^ORCID,Chédotal Alain³^ORCID,Bayraktar Omer¹^ORCID,Roberts Irene¹⁶^ORCID,Jardine Laura¹²^ORCID,Göttgens Berthold⁴^ORCID,Teichmann Sarah A.¹¹⁷^ORCID,Haniffa Muzlifah¹²¹⁸^ORCID

Affiliation:

1. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

2. Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

3. Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.

4. Department of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 0AW, UK.

5. MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CD2 0QH, UK.

6. Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.

7. Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

8. Centre Nacional d’Analisi Genomica-Centre de Regulacio Genomica (CNAG-CRG), Barcelona Institute of Science and Technology (BIST), Barcelona, Spain.

9. NovoPath, Department of Pathology, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.

10. Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

11. EMBL-EBI, Wellcome Genome Campus, Cambridge CB10 1SD, UK.

12. CRUK Cambridge Institute, University of Cambridge, Cambridge CB2 0RE, UK.

13. MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

14. Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA.

15. Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.

16. Department of Paediatrics, University of Oxford, Oxford OX3 9DS, UK.

17. Theory of Condensed Matter Group, Department of Physics, Cavendish Laboratory, University of Cambridge, Cambridge CB3 0HE, UK.

18. Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE1 4LP, UK.

Abstract

The extraembryonic yolk sac (YS) ensures delivery of nutritional support and oxygen to the developing embryo but remains ill-defined in humans. We therefore assembled a comprehensive multiomic reference of the human YS from 3 to 8 postconception weeks by integrating single-cell protein and gene expression data. Beyond its recognized role as a site of hematopoiesis, we highlight roles in metabolism, coagulation, vascular development, and hematopoietic regulation. We reconstructed the emergence and decline of YS hematopoietic stem and progenitor cells from hemogenic endothelium and revealed a YS-specific accelerated route to macrophage production that seeds developing organs. The multiorgan functions of the YS are superseded as intraembryonic organs develop, effecting a multifaceted relay of vital functions as pregnancy proceeds.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.add7564

Reference88 articles.

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