Inhibition of Toxic Epidermal Necrolysis by Blockade of CD95 with Human Intravenous Immunoglobulin-Reference-Cited by-同舟云学术

Inhibition of Toxic Epidermal Necrolysis by Blockade of CD95 with Human Intravenous Immunoglobulin

Published:1998-10-16 Issue:5388 Volume:282 Page:490-493
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Viard Isabelle¹,Wehrli Philippe¹,Bullani Roberto¹,Schneider Pascal¹,Holler Nils¹,Salomon Denis¹,Hunziker Thomas¹,Saurat Jean-Hilaire¹,Tschopp Jürg¹,French Lars E.¹

Affiliation:

1. I. Viard, P. Wehrli, R. Bullani, D. Salomon, J.-H. Saurat, L. E. French, Department of Dermatology, Geneva University Medical School, CH-1211 Geneva 4, Switzerland. P. Schneider, N. Holler, J. Tschopp, Institute of Biochemistry, University of Lausanne, BIL Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland. T. Hunziker, Department of Dermatology, University of Bern, Medical School, CH-3010 Bern, Switzerland.

Abstract

Toxic epidermal necrolysis (TEN, Lyell's syndrome) is a severe adverse drug reaction in which keratinocytes die and large sections of epidermis separate from the dermis. Keratinocytes normally express the death receptor Fas (CD95); those from TEN patients were found to express lytically active Fas ligand (FasL). Antibodies present in pooled human intravenous immunoglobulins (IVIG) blocked Fas-mediated keratinocyte death in vitro. In a pilot study, 10 consecutive individuals with clinically and histologically confirmed TEN were treated with IVIG; disease progression was rapidly reversed and the outcome was favorable in all cases. Thus, Fas-FasL interactions are directly involved in the epidermal necrolysis of TEN, and IVIG may be an effective treatment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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