Cell competition during reprogramming gives rise to dominant clones-Reference-Cited by-同舟云学术

Cell competition during reprogramming gives rise to dominant clones

Published:2019-04-26 Issue:6438 Volume:364 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shakiba Nika¹^ORCID,Fahmy Ahmed²,Jayakumaran Gowtham²³,McGibbon Sophie⁴^ORCID,David Laurent⁵⁶⁷,Trcka Daniel³^ORCID,Elbaz Judith³,Puri Mira C.³⁸^ORCID,Nagy Andras³⁹¹⁰¹¹^ORCID,van der Kooy Derek²¹²,Goyal Sidhartha¹⁴,Wrana Jeffrey L.²³^ORCID,Zandstra Peter W.¹¹²¹³¹⁴¹⁵^ORCID

Affiliation:

1. Institute of Biomaterials and Biomedical Engineering (IBBME), University of Toronto, Toronto, Ontario M5S 3E1, Canada.

2. Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

3. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

4. Department of Physics, University of Toronto, Toronto, Ontario M5S 1A7, Canada.

5. SFR-SANTE, iPSC Core Facility, INSERM, CNRS, UNIV Nantes, CHU Nantes, Nantes, France.

6. CRTI, INSERM, Université de Nantes, Nantes, France.

7. ITUN, CHU Nantes, Nantes, France.

8. Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5T 3H7, Canada.

9. Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario M5G 1E2, Canada.

10. Institute of Medical Science, University of Toronto, Toronto, Ontario M5T 3H7, Canada.

11. Australian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.

12. The Donnelly Centre for Cellular and Biomolecular Research (CCBR), University of Toronto, Toronto, Ontario M5S 3E1, Canada.

13. School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

14. The Biomedical Research Centre, The University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

15. Michael Smith Laboratories, The University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada.

Abstract

Domination in the stem cell world A Nobel Prize–winning discovery showed that specialized cells can be genetically reprogrammed into stem cells, thus gaining the ability to become any cell type in the body. But what happens during reprogramming is not completely understood. Shakiba et al. used experimental and mathematical approaches to show that skin cells compete during reprogramming, eliminating one another as the population progresses toward the stem cell state (see the Perspective by Wolff and Purvis). The “winners” are a special class of skin cells originating from the neural crest. Cells of this type normally emerge during embryonic development and migrate into various tissues, including the skin, muscle, and nervous system. Science , this issue p. eaan0925 ; see also p. 330

Funder

CIHR

Medicine by Design

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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