Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β-Reference-Cited by-同舟云学术

Postnatal Sex Reversal of the Ovaries in Mice Lacking Estrogen Receptors α and β

Published:1999-12-17 Issue:5448 Volume:286 Page:2328-2331
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Couse J. F.¹,Hewitt S. Curtis¹,Bunch D. O.²,Sar M.³,Walker V. R.¹,Davis B. J.⁴,Korach K. S.¹

Affiliation:

1. Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology,

2. Laboratory of Reproductive Biology, Department of Cell Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

3. Chemical Industry Institute of Toxicology, Research Triangle Park, NC 27709, USA.

4. Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

Abstract

Mice lacking estrogen receptors α and β were generated to clarify the roles of each receptor in the physiology of estrogen target tissues. Both sexes of αβ estrogen receptor knockout (αβERKO) mutants exhibit normal reproductive tract development but are infertile. Ovaries of adult αβERKO females exhibit follicle transdifferentiation to structures resembling seminiferous tubules of the testis, including Sertoli-like cells and expression of Müllerian inhibiting substance, sulfated glycoprotein-2, and Sox9 . Therefore, loss of both receptors leads to an ovarian phenotype that is distinct from that of the individual ERKO mutants, which indicates that both receptors are required for the maintenance of germ and somatic cells in the postnatal ovary.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference41 articles.

1. Weniger J. P., J. Dev. Physiol. 14, 303 (1990).

2. Fisher R., Graves K. H., Parlow A. F., Proc. Natl. Acad. Sci. U.S.A. 95, 6965 (1998);

3. Robertson K. M., et al., Proc. Natl. Acad. Sci. U.S.A. 96, 7986 (1999).

4. Couse J. F., Korach K. S., Endocr. Rev. 20, 358 (1999).

5. αβERKO mice were generated by breeding heterozygous mice from the previously described αERKO and βERKO lines [

Cited by 517 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Possible role of apelin on the ovarian steroidogenesis and uterine apoptosis of infantile mice: An in vitro study;The Journal of Steroid Biochemistry and Molecular Biology;2024-04

2. Regulation of Follicular Development in Chickens: WIF1 Modulates Granulosa Cell Proliferation and Progesterone Synthesis via Wnt/β-Catenin Signaling Pathway;International Journal of Molecular Sciences;2024-02-01

3. Single-cell sequencing reveals transcriptional dynamics regulated by ERα in mouse ovaries;2023-12-13

4. The endometrial transcriptome transition preceding receptivity to embryo implantation in mice;BMC Genomics;2023-10-04

5. International Union of Basic and Clinical Pharmacology CXIII: Nuclear Receptor Superfamily—Update 2023;Pharmacological Reviews;2023-08-16