Early developmental asymmetries in cell lineage trees in living individuals-Reference-Cited by-同舟云学术

Early developmental asymmetries in cell lineage trees in living individuals

Published:2021-03-19 Issue:6535 Volume:371 Page:1245-1248
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Fasching Liana¹^ORCID,Jang Yeongjun²^ORCID,Tomasi Simone¹,Schreiner Jeremy¹^ORCID,Tomasini Livia¹^ORCID,Brady Melanie V.¹^ORCID,Bae Taejeong²^ORCID,Sarangi Vivekananda²,Vasmatzis Nikolaos²^ORCID,Wang Yifan²^ORCID,Szekely Anna³^ORCID,Fernandez Thomas V.¹⁴^ORCID,Leckman James F.¹⁴,Abyzov Alexej²^ORCID,Vaccarino Flora M.¹⁵⁶^ORCID

Affiliation:

1. Child Study Center, Yale University, New Haven, CT 06520, USA.

2. Department of Quantitative Health Sciences, Center for Individualized Medicine, Mayo Clinic, Rochester, MN 55905, USA.

3. Department of Neurology, Yale University, New Haven, CT 06520, USA.

4. Department of Psychiatry, Yale University, New Haven, CT 06520, USA.

5. Department of Neuroscience, Yale University, New Haven, CT 06520, USA.

6. Yale Kavli Institute for Neuroscience, New Haven, CT 06520, USA.

Abstract

Genomic sleuthing spots early divergence After fertilization, the human zygote divides into two cells. Fasching et al. used genomic analysis from cellular samples taken much later in development to back-calculate the cell division trees that went before. Although the first cell division in human development looks symmetrical from the outside, the fates followed by daughter cells from each of those first two blastomeres are anything but the same. As much as 90% of blood cells are derived from just one of the first two blastomeres. Science , this issue p. 1245

Funder

National Institute of Mental Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference19 articles.

1. Different mutational rates and mechanisms in human cells at pregastrulation and neurogenesis

2. Asymmetrical volumes of the right and left frontal and occipital regions of the human brain

3. Pervasive lesion segregation shapes cancer genome evolution

4. Microsatellite mutations in the germline:

Cited by 50 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Building the brain mosaic: an expanded view;Trends in Genetics;2024-09

2. Proteome asymmetry in mouse and human embryos before fate specification;2024-08-26

3. Somatic nuclear mitochondrial DNA insertions are prevalent in the human brain and accumulate over time in fibroblasts;PLOS Biology;2024-08-22

4. Revisiting trophectoderm-inner cell mass lineage segregation in the mammalian preimplantation embryo;Human Reproduction;2024-06-26

5. Transgenerational transmission of post-zygotic mutations suggests symmetric contribution of first two blastomeres to human germline;2024-06-22