Caspases: Enemies Within-Reference-Cited by-全球学者库

Caspases: Enemies Within

Published:1998-08-28 Issue:5381 Volume:281 Page:1312-1316
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Thornberry Nancy A.¹,Lazebnik Yuri¹

Affiliation:

1. N. A. Thornberry is in the Department of Biochemistry, Merck Research Laboratories, R80W-250, Post Office Box 2000, Rahway, NJ 07065, USA. Y. Lazebnik is at Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Abstract

REVIEW Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this machinery is a proteolytic system involving a family of proteases called caspases. These enzymes participate in a cascade that is triggered in response to proapoptotic signals and culminates in cleavage of a set of proteins, resulting in disassembly of the cell. Understanding caspase regulation is intimately linked to the ability to rationally manipulate apoptosis for therapeutic gain.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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