Control of T Helper Cell Differentiation--in Search of Master Genes

Author:

Dong Chen,Flavell Richard A.12

Affiliation:

1. C. Dong is at the Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

2. R. A. Flavell is at the Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, 310 Cedar Street, New Haven, CT 06520, USA.

Abstract

Naïve T helper (T H 0) cells can differentiate into one of two distinct populations: T H 1 and T H 2. Each population is characterized by the expression of specific cytokines and their ability to participate in cell-mediated or humoral immune responses. Recent efforts at identifying the molecular mechanisms through which T H 0 cells become T H 1 or T H 2 cells have been promising. A number of transcription factors, including GATA-3 and T-bet, have been identified that promote the differentiation of T H 0 cells and the maintenance of the differentiated cell phenotype. Dong and Flavell review recent findings on proteins that control the fate of T H 0 differentiation, whether by promotion or inhibition, and discuss the role of epigenesis in the differentiation process.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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