Chinese Journal of Experimental Traditional Medical Formulae. 2014, (16) Core

The Treatment of No-reflow Occurring During Percutaneous Coronary Intervention on the Pathogenesis of Insidious PhlegmChinese Full Text

BAI Xiao-jun;REN Jian-xun;Department of Cardiology,the First Affiliated Hospital of XI’AN Jiao Tong University;Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Chinese Materia Pharmacology;

Abstract: Myocardial no-reflow phenomenon still have induced the incidence of major cardiovascular events after percutaneous coronary intervention in patients with acute myocardial infarction and can severe affect the prognosis,and its pathological proecsses includes vascular endothelial injury,inflammatiory reaction,oxygen free radical damage and platelet activation,etc. Although many drugs have been studied for intervention of specific pathological proecsses in no-reflow phenomenon,the effects were rarely observed because of its single target intervention. So it is urgent to resolve that how to improve blood flow perfusion of myocardium microcirculation after revascularization for acute myocardial infarction. Traditional Chinese medicines have been taken on significant effects on myocardial no-reflow phenomenon although few reports are showed. We deduced that insidious phlegm blocking collaterals was the major pathogenesis of myocardial no-reflow phenomenon after myocardial ischemia reperfusion by analysis of related literature under the guidance of the basic theory of traditional Chinese medicine（ TCM）,and insidious phlegm could closely relate to the hyperlipidemia and inflammation. The interaction between the hyperlipidemia and inflammation in pathophysiological processes demonstrated pathogenic characteristics of the phlegm inducing blood stasis and phlegm-stasis blocking collaterals in TCM,that is basic cause leading to poor effects and prognosis of PCI. Thus,it is an important method to improve no-reflow or slow blood flow after PCI that applying treatment of boosting qi for resolving phlegm and promoting blood circulation for removing obstructionin collaterals. This method could combine multiple effects in pathological proecsses of myocardial ischemia reperfusion and delay the endpoint events,so that improve the quality of life and reduce mortality at maximun degree. There is no doubt that the effective methods of myocardial no-reflow prevention and treatment are well widen in clinical medicine of TCM,which has the certain directive meaning in clinically.

Keywords：

percutaneous coronary intervention; no-reflow; insidious phlegm; pathogenesis;

DOI：
10.13422/j.cnki.syfjx.2014160237
Series：
Subject：
Classification Code：
R542.22

Mobile Reading

Read on your phone instantly

Step 1
Scan QR Codes

"Mobile CNKI-CNKI Express" App

Step 2
Open“CNKI Express”

and click the scan icon in the upper left corner of the homepage.

Step 3
Scan QR Codes

Read this article on your phone.
HTML
CAJ Download
PDF Download

Contents

The Treatment of No-reflow Occurring During Percutaneous Coronary Intervention on the Pathogenesis of Insidious PhlegmChinese Full Text

BAI Xiao-jun;REN Jian-xun;Department of Cardiology,the First Affiliated Hospital of XI’AN Jiao Tong University;Institute of Basic Medical Sciences of Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing Key Laboratory of Chinese Materia Pharmacology;

Read on your phone instantly

Citation Network

Related Literature