Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Their Corresponding 2(1H)Thiones Using Trichloroacetic Acid as a Catalyst under Solvent-Free Conditions-Reference-Cited by-同舟云学术

Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Their Corresponding 2(1H)Thiones Using Trichloroacetic Acid as a Catalyst under Solvent-Free Conditions

Published:2012-11-14 Issue: Volume:2012 Page:1-4
ISSN:2090-5157
Container-title:ISRN Organic Chemistry
language:en
Short-container-title:ISRN Organic Chemistry

Author:

Karimi-Jaberi Zahed¹,Moaddeli Mohammad Sadegh¹

Affiliation:

1. Department of Chemistry, Firoozabad Branch, Islamic Azad University, P.O. Box 74715-117, Firoozabad, Fars, Iran

Abstract

Trichloroacetic acid was found to be a convenient catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones and their corresponding 2(1H)-thiones through a one-pot three-component reaction of aldehydes, alkyl acetoacetate, and urea or thiourea at 70°C under solvent-free conditions.

Publisher

Hindawi Limited

Subject

General Medicine

Link

http://downloads.hindawi.com/archive/2012/474626.pdf

Reference27 articles.

1. MCM-41 anchored sulfonic acid (MCM-41-R-SO3H): A mild, reusable and highly efficient heterogeneous catalyst for the Biginelli reaction

2. An efficient and solvent-free one-pot synthesis of dihydropyrimidinones under microwave irradiation

3. One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones using chloroacetic acid as catalyst

4. One-Pot synthesis of dihydropyrimidinones by dodecylphosphonic acid as solid Bronsted Acid Catalyst under Solvent-Free Conditions via Biginelli condensation

5. Ion exchange resins as recyclable and heterogeneous solid acid catalysts for the Biginelli condensation: An improved protocol for the synthesis of 3,4-dihydropyrimidin-2-ones

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