Case Report: Synchronous primary location of gastrointestinal stromal tumors (GIST) and adenocarcinoma of the colon: an unusual occurrence

Author:

Sghaier AsmaORCID,El Ghali Amine,Fradi Khalil,Chiba Dorra,Hamila Fehmi,Youssef Sabri

Abstract

Background: We have little knowledge about the synchronous occurrence of gastrointestinal stromal tumors (GISTs) and other types of histologic tumors. This association is very rare. Case presentation: We describe a case of synchronous stromal tumor and adenocarcinoma of the left side colonic localization. Immunohistochemistry identified c-Kit expression. The discovery of colonic adenocarcinoma was on operative specimen after histologic examination. The patient underwent left carcinologic colectomy with stoma. Follow-up at one year postoperatively did not detect tumor recurrence. Discussion: Clinical implications of the association between these two neoplasms are not clearly described. Treatment depends on the dominance of one histologic type. Knowledge of the genetic data of this association offers opportunity of treatment with the new targeted-therapy molecules. Surgical resection, may remain the curative treatment. Conclusions: Synchronous adenocarcinoma and GIST has been more commonly described in the stomach.  The pathogeneses of tumorigenesis may not be the same for the two tumors. More studies seem be necessary to clarify a potential role of different genes in the development of adenocarcinomas. And therefore, above all their therapeutic implications

Publisher

F1000 Research Ltd

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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