Abstract
The human and animal pathogens Yersinia pestis, which causes bubonic and pneumonic plague, and Yersinia pseudotuberculosis and Yersinia enterocolitica, which cause gastroenteritis, share a type 3 secretion system which injects effector proteins, Yops, into host cells. This system is critical for virulence of all three pathogens in tissue infection. Neutrophils are rapidly recruited to infected sites and all three pathogens frequently interact with and inject Yops into these cells during tissue infection. Host receptors, serum factors, and bacterial adhesins appear to collaborate to promote neutrophil–Yersinia interactions in tissues. The ability of neutrophils to control infection is mixed depending on the stage of infection and points to the efficiency of Yops and other bacterial factors to mitigate bactericidal effects of neutrophils. Yersinia in close proximity to neutrophils has higher levels of expression from yop promoters, and neutrophils in close proximity to Yersinia express higher levels of pro-survival genes than migrating neutrophils. In infected tissues, YopM increases neutrophil survival and YopH targets a SKAP2/SLP-76 signal transduction pathway. Yet the full impact of these and other Yops and other Yersinia factors on neutrophils in infected tissues has yet to be understood.
Funder
National Institutes of Health
Subject
General Pharmacology, Toxicology and Pharmaceutics,General Immunology and Microbiology,General Biochemistry, Genetics and Molecular Biology,General Medicine
Reference88 articles.
1. Yersinia pestis, the cause of plague, is a recently emerged clone of Yersinia pseudotuberculosis.;M Achtman;Proc Natl Acad Sci U S A.,1999
2. Yersinia virulence factors - a sophisticated arsenal for combating host defences [version 1; peer review: 2 approved].;S Atkinson;F1000Res.,2016
3. Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors.;J Bliska;Cell Microbiol.,2013
4. The role of transition metal transporters for iron, zinc, manganese, and copper in the pathogenesis of Yersinia pestis.;R Perry;Metallomics.,2015
5. Regulation of the Yersinia type III secretion system: traffic control.;R Dewoody;Front Cell Infect Microbiol.,2013
Cited by
11 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献