Systematic Qualitative Proteome-wide Analysis of Lysine Malonylation Profiling in Platycodon grandiflorus

Author:

Yang Qingshan1,Xu Shaowei1,Jiang Weimin2,Meng Fei1,Wang Shuting1,Sun Zongping3,Zha Liangping1,Gui Shuangying1,Peng Daiyin1,Liu Juan1,Xing Shihai1

Affiliation:

1. Anhui University of Chinese Medicine

2. Hengyang Normal University

3. Chinese Herbal Medicine, Fuyang Normal University

Abstract

Abstract Background The modification of lysine malonylation found in recent years can affect biological metabolism and play an important role in life activities. Platycodon grandiflorus, as an economic crop and medicinal plant with a wide range of applications and has broad prospects for development. However, there is no reports on malonylation in the related research of P. grandiflorus. This study qualitatively introduces the malonylation of lysine in P. grandiflorus. Results 888 lysine malonylation modified proteins in P. grandiflorus were identified, with a total of 1755 modification sites. According to the functional annotation, malonylation proteins were closely related to catalysis, binding and other reactions. Subcellular localization showed that related proteins were enriched in chloroplasts, cytoplasm and nuclei, indicating that this modification could regulate a variety of biological metabolic processes. Motif analysis showed that the enrichment of Alanine (A), Cysteine (C), Glycine (G) and Valine (V) amino acids surrounding malonylated lysine residues. Metabolic pathway and protein-protein interaction network analyses suggested modification is mainly involved in plant photosynthesis. Moreover, malonylated proteins also involved in stress and defense responses. Conclusion This study shows that lysine malonylation can affect a variety of biological processes and metabolic pathways, and these contents are reported for the first time in P. grandiflorus, which can provide important information for further research on P. grandiflorus and lysine malonylation.

Publisher

Research Square Platform LLC

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