Aging and putative frailty biomarkers are altered by spaceflight-Reference-Cited by-同舟云学术

Aging and putative frailty biomarkers are altered by spaceflight

Published:2023-02-23 Issue: Volume: Page:
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Author:

Camera Andrea¹,Tabetah Marshall²,Castañeda Verónica³^ORCID,Kim JangKeun⁴,Singh Aman⁵^ORCID,Haro-Vinueza Alissen⁶,Salinas Ivonne⁶,Seylani Allen⁷,Arif Shehbeel⁸,Das Saswati⁹,Mori Marcelo¹⁰^ORCID,Carano Anthony¹¹^ORCID,De Oliveira Lorraine Christine¹²,Muratani Masafumi¹³^ORCID,Barker Richard¹⁴,Zaksas Victoria¹⁵^ORCID,Goel Chirag¹⁶,Dimokidis Eleni¹⁷,Taylor Deanne¹⁸,Jeong Jisu¹⁹,Overbey Eliah⁴,Meydan Cem⁴^ORCID,Porterfield D. Marshall²,Díaz Juan⁶,Caicedo Andrés²⁰,Schisler Jonathan²¹^ORCID,Laiakis Evagelia²²,Mason Christopher⁴^ORCID,Kim Man¹⁹,Karouia Fathi²³^ORCID,Szewczyk Nathaniel¹¹^ORCID,Beheshti Afshin²⁴

Affiliation:

1. University of Oslo

2. Purdue University

3. Universidad de los Andes

4. Weill Cornell Medicine

5. University of Aberdeen

6. Universidad San Francisco de Quito

7. University of California, Riverside

8. Center for Data-Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia

9. Atal Bihari Vajpayee Institute of Medical Sciences

10. Institute of Biology, University of Campinas (Unicamp)

11. Ohio University

12. Federal University of São Paulo

13. University of Tsukuba

14. University of Wisconsin-Madison

15. Clever Research Lab, L.L.C.

16. Northwestern University Feinberg School of Medicine

17. Amazon Web Services, Asia Pacific & Japan

18. Children's Hospital of Philadelphia

19. School of Medicine, Kyung Hee University

20. Instituto de Investigaciones en Biomedicina iBioMed, Universidad San Francisco de Quito

21. The University of North Carolina at Chapel Hill, Chapel Hill

22. Georgetown University

23. NASA Ames Research Center

24. Broad Institute of MIT and Harvard

Abstract

Abstract Human space exploration is hazardous, causing molecular changes that can alter astronauts' health. This can include genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and epigenomic changes. These alterations are similar to changes during aging on Earth. However, little is known about the link between these changes and disease development in space. Frailty syndrome is a robust predictor associated with biological aging, however its existence during spaceflight has not been examined. We used murine data from NASA’s GeneLab and astronaut data from JAXA and Inspiration4 missions to evaluate the presence of biological markers and pathways related to frailty, aging and sarcopenia. We identified changes in gene expression that could be related to the development of a frailty-like condition. These results suggest that the parallels between spaceflight and aging may extend to frailty as well. Future studies examining the utility of a frailty index in monitoring astronaut health appear warranted.

Publisher

Research Square Platform LLC

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