Analysis of related factors of portal vein thrombosis in liver cirrhosis

Abstract

Abstract Background and aims: To investigate the usefulness of IL-6、TNF-α、Protein C(PC) and Thromboelastography (TEG) to serve as a predictor of portal vein thrombosis (PVT) in patients with liver cirrhosis. At the same time, we explored the clinical significance of the above indicators in the disease progression. Methods: A total of 123 patients with liver cirrhosis were recruited from May 2021 to December 2021, according to the imaging findings. They were divided into the PVT group (n=52) and the non-PVT group (n=71). Furthermore, patients with PVT were divided into plasma transfusion groups (n=13) and non-plasma transfusion groups (n=39). The basic general information, past medical history, laboratory, and imaging examination data were collected and analyzed. Results: In univariate analysis, there was no significant difference in IL-6, PC, R, Angle, MA, and CI between the two groups (P > 0.05). TNF-α in the PVT group was significantly lower than that in the non-PVT group (P =0.001). K in the PVT group was significantly higher than that in the non-PVT group (P =0.031) There was no significant difference in IL-6, TNF-α, PC, or TEG between different Child-Pugh classification groups (P＞0.05). There was no significant difference in TEG between the plasma transfusion group and the non-plasma transfusion group. In Binary logistic regression analysis, TNF-α (OR=0.9881,95%CI=0.971,0.990,P＜0.001) ,K(OR=1.28,95%=1.053,1.569，P=0.014) ,APTT (OR=0.753,95%CI=0.656,0.865,P＜0.001) , diameter of portal vein (OR=1.310,95%CI=1.108，1.549，P=0.002）and the history of splenectomy or embolism (OR=7.565,95%CI=1.514，37.799，P=0.014）were related to the formation of PVT. Conclusions: TNF-α, K, APTT, the diameter of the portal vein and the history of splenectomy or embolism were the related factors of PVT formation, but IL-6 was not related to the formation of PVT.