Global Burden And Trends of Lung Cancer Incidence And Mortality

Abstract

Abstract Objective: Lung cancer is the leading cause of cancer-related deaths around the world for many years. The aim of this study is to investigate the global patterns and trends of lung cancer, and expects to promote health education and sustainable cancer prevention measures.Methods: Lung cancer incidence and mortality were derived from GLOBOCAN 2020 database. Continued data from Cancer Incidence in Five Continents Time Trends was used to analyze the temporal trends from 2000 to 2012 by using Joinpoint regression, and annual average percent changes were calculated. The association between Human Development Index and lung cancer incidence and mortality were assessed by linear regression.Results: An estimated 2.2 million new lung cancer cases and almost 1.8 million lung cancer deaths occurred in 2020. The age-standardized incidence ranged from 36.8 per 100 000 in Demark from 5.9 per 100 000 in Mexico. The age-standardized mortality rates varied from 32.8 in Poland to 4.9 in Mexico. Both the age-standardized incidence and mortality rates were about 2 times higher in men than in women. The ASIR of lung cancer were downward trend in United States of America (USA) between 2000 and 2012, which was more prominent in males. The age-specific incidence rates of male and female lung cancer in the age group of 50-59 years were upward trend in China. Conclusions: The burden of lung cancer is still not optimistic, especially in developing countries like China. Taking into consideration the effectiveness of tobacco control and screening in developed countries, such as USA, we need to further strengthen health education, accelerate the establishment of tobacco control policies and regulations, and improve the early cancer screening awareness to curb the future lung cancer burden.