Affiliation:
1. Digestive Department, Tinglin Hospital
2. Shanghai Fengneng Digital Health Technology Research Institute
Abstract
Abstract
BACKGROUD: Colorectal cancer has an extremely high incidence and mortality rate, and early detection and treatment is important for health.
METHODS: DEmiRNAs were searched for in different datasets. core DEmiRNAs were identified by one-factor cox analysis and target genes were predicted using targetscan and miRDB. Select intersections of target genes and DEmRNAs to identify key genes by survival analysis.
RESULTS: Three miRNAs in COAD and two miRNAs in READ were identified as core DEmiRNAs. After searching for targeted mRNA and conducting survival and expression analysis, it was found that hsa-mir-296-TNSF15 and hsa-mir-744-TNSF15 are effective regulatory networks in colorectal cancer.
CONCLUSION: This study identified hsa-mir-296-TNSF15 and hsa-mir-744-TNSF15 as effective regulatory networks related to the prognosis of colorectal cancer.
Publisher
Research Square Platform LLC
Reference22 articles.
1. "MicroRNA–mRNA interactions in colorectal cancer and their role in tumor progression." Genes;Amirkhah R;Chromosomes and Cancer,2015
2. Arvelo, F., F. Sojo and C. Cotte (2015). "Biology of colorectal cancer." Ecancermedicalscience 9.
3. "RETRACTED: miR-744-5p Inhibits Non-Small Cell Lung Cancer Proliferation and Invasion by Directly Targeting PAX2.";Chen S;Technology in Cancer Research & Treatment,2019
4. "Aloperine inhibits proliferation and promotes apoptosis in colorectal cancer cells by regulating the circNSUN2/miR-296-5p/STAT3 pathway." Drug Design;Han W;Development and Therapy,2021
5. "miR-296 inhibits the metastasis and epithelial-mesenchymal transition of colorectal cancer by targeting S100A4.";He Z;BMC cancer,2017