The risk of breast cancer is associated with rs1800872 genetic variation. A cohort study

Abstract

Abstract Many women across the globe are afflicted with breast cancer, making it one of the most prevalent forms of the disease. Changes to single nucleotides in crucial genes may affect one's likelihood of contracting the illness. This study was intended to see if alterations in the nucleotide sequence of one particular interleukin 10 gene, called rs1800872, could have an effect on the probability of getting breast cancer. A study was performed to look at the correlation between single nucleotide polymorphisms in the interleukin 10 gene and the occurrence of breast cancer by comparing two hundred women composed of 150 with the disease and 150 healthy controls. Genomic DNA was isolated from the study participants to identify the genotype of the samples at the rs1800872 polymorphism site. The analysis found that having one copy of the rs1800872 CA genotype and its related allele, A, increased the likelihood of breast cancer when compared against being in the heterozygous or allelic models. Furthermore, categorized analysis revealed a strong association with the size of the tumor but not with lymph node metastasis. From these results, rs1800872 polymorphism can be regarded as a potential genetic risk factor for breast cancer.