Analysis of correlation between Klebsiella pneumoniae resistance and antibiotic use density in ICU of a hospital in China : A Retrospective Study, 2020-2022

Abstract

Abstract Objective To analyze the correlation between antimicrobial resistance of Klebsiella pneumoniae in ICU and the use of antibiotics, to provide evidence and reference for rational use of antibiotics and prevention and control of multi-drug resistant bacteria. Methods The composition ratio and the antibiotic resistance rate of Klebsiella pneumoniae isolated in ICU from 2020 to 2022 was analyzed retrospectively, as well as the correlation between the antibiotic use density and antibiotic resistance were analyzed. Results 971 strains of Klebsiella pneumoniae isolated from ICU for three years were selected. The samples were mainly derived from sputum (72.50%), urine (10.40%), drainage fluid (7.00%), blood (6.80%). The antibiotic resistance rate of Klebsiella pneumoniae was 48.6%, and there was significant difference in the antibiotic resistance rate of all kinds of antibiotics (P < 0.001).The resistance rate of Klebsiae pneumoniae to β-lactam and quinolone antibiotics was higher (> 50%). The resistance rate to Carbapenems, aminoglycosides and sulfonamides was relatively low (< 40%). There was a significant positive correlation between the resistance rate of Klebsiella pneumoniae and the antibiotics use density (P < 0.05). Conclusion The antibiotic resistance of Klebsiella pneumoniae is severe, which is significantly related to the antibiotic use density. We should strengthen the management of antibiotic, and strictly implement the prevention and control measures of multi-drug resistant bacteria to reduce the spread of resistant.