Comprehensive management analysis of 75 deceased donors maintained in ICU: a single center experience

Abstract

Abstract Objective To summarize and analyze the integrated management program of 75 deceased donors maintained in ICU of our hospital, so as to promote the development of organ transplantation. Methods The data deceased donors maintained in ICU of our hospital from June 2020 to January 2022 were collected. The basic data, laboratory examination results, disease distribution and maintenance measures were retrospectively studied. Results 75 patients were included, with a sex ratio (M/F) of 90.67% vs 9.33%, a median age of 55, a median ICU length of 4 days. Donors with higher APACHE II scores tended to enter the donation process faster (P=0.001). The primary disease of donors was mainly cerebral hemorrhage (53, 70.67%). 53 pathogens were detected in 58 patients (infection rate: 77.33%), mainly bacteria (42, 79.25%, Gram-negative mainly), Klebsiella pneumoniae, Acinetobacter baumannii and Escherichia coli were the most detected. 96.00% (72/75) donors successfully completed donation, mainly donation after cardiac death (65, 86.67%). 229 large organs and tissues were obtained from 72 donors, with an acquisition ratio of 1:3.14. The acquisition ratio of donors of different ages was statistically different (P<0.001). The overall organ utilization rate was 96.51% (221/229), and the kidney utilization rate in our hospital was 95.14% (137/144). Conclusion ICU plays an irreplaceable role in organ transplantation. ICU staffs familiarize the integrated management program of deceased donors, which is helpful to promote the development of organ transplantation.