Association of Oxidative Stress-related Biomarkers and Atrial Fibrillation: A Cross- Sectional Study

Abstract

Abstract A growing number of reports have shown that oxidative stress is an important contributing factor for atrial fibrillation (AF). The identification of oxidative stress-related blood biomarkers for patients with AF has great significance for the early prevention and treatment of AF. The purpose of this study was to illuminate the relationship of several blood markers of oxidative stress with AF. This study enrolled hospitalized patients from January 2018 to December 2020 at the Department of Cardiology in a tertiary center in east China.Clinical data, with an emphasis on oxidative stress-related blood biomarkers, were collected to assess their relationship with AF. A total of 9452 patients were enrolled, including 1244 patients with AF (13.16%). Elevated total bilirubin (OR: 1.056; 95% CI: 1.046-1.065; P<0.001), uric acid (OR: 1.157; 95% CI: 1.112-1.204; P<0.001) and reduced superoxide dismutase(OR: 0.992; 95% CI: 0.987-0.997; P=0.001) were significantly associated with AF, which were also effective indicators for diagnosing AF (the area under the ROC curve model combined with uric acid, total bilirubin and superoxide dismutase was 69.1%). Furthermore, oxidative stress-related biomarkers were significantly associated with the prevalence of AF in different ages and sexes. As oxidative stress-related biomarkers, higher levels of total bilirubin and uric acid and lower levels of superoxide dismutase were independently associated with the prevalence of AF. These biomarkers may be used as potential indicators to predict AF, and multitarget antioxidant therapy may be a reasonable approach to prevent and treat AF.