A Meta-Analysis for the Association of MATN1 Gene rs20566 Polymorphism with Mandibular Prognathism

Abstract

Abstract Mandibular prognathism (MP) is disfigurement of mandible which can be seen as an overgrowth of mandible without proper development of maxilla. Matrilin-1 was shown to regulate the formation of cartilage matrix and to promote chondrocyte differentiation. The aim of this meta-analysis is to synthesize evidence regarding the link between MP risk and the rs20566 polymorphism in the MATN1 gene. Relevant publications were retrieved by searching the PubMed, Web of Science, and Google Scholar databases. The association between MP and the MATN1 gene rs20566 polymorphism was assessed by calculating odds ratios (ORs) and 95% CIs. Between study heterogeneity was identified using Cochrane Q test and I2 statistics. To assess robustness of the meta-analysis sensitivity analysis was performed. Funnel plots and Egger’s test were used to know publication bias. The web tool MetaGenyo was used to conduct a meta-analysis. A total of three Asian studies with 246 MP subjects and 204 healthy controls were eventually taken for meta-analysis. Overall, the MATN1 rs20566 polymorphism is not associated with elevated risk of MP (Dominant genetic model / AA + AG versus GG OR = 1.35, 95% CI = 0.32–5.67). The degree of heterogeneity is found to be large as it falls between 75–100% (I2=89% p = < 0.01). Furthermore, this meta-analysis provides no evidence of publication bias (p = 0.696). In conclusion, this meta-analysis did not provide the evidence for the link between MATN1 gene polymorphism in MP. As the present meta-analysis included only three studies related Asian populations and results also conflict with the biological plausibility that matrilin-1 levels modulate cartilage development, need careful interpretation and future research.