Affiliation:
1. Shi’s Center of Orthopedics and Traumatology, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai
2. School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai
Abstract
Abstract
Background
We aimed to investigate the interaction between serum uric acid levels with estimated glomerular filtration rate (eGFR) to low muscle strength (LMS) in a large Chinese elderly population.
Methods
Cohort data were obtained from China Health and Retirement Longitudinal Study (CHARLS) in 2011 and 2015. Two thousand seven hundred forty-five community-dwelling older participants were enrolled for the follow-up. Serum uric acid was collected after 8 hours of fasting, and handgrip strength was measured with a dynamometer. eGFR was calculated with an equation based on the Chinese population. A generalized additive model was employed for interaction analysis and progressively adjusted confounders.
Results
In this study, we found that men with a low eGFR (<60 mL/min/1.73 m2) reported higher SUA levels (5.91 ± 1.27) and older (72.53 ± 6.38) than those who had a high eGFR while women share the same difference with a lower eGFR in higher SUA levels (5.00 ± 1.34) and older (72.81 ± 6.83). After progressively adjusting covariates, in females, the OR for higher eGFR with higher SUA level remained significantly with low muscle strength (OR=0.80 95%CI=0.68-0.95 P=0.0102). This correlation, however, was not observed in men.
Conclusions
This population-based cohort study in Chinese revealed that high serum uric acid level with higher eGFR seems to be significantly associated with a lower risk of low muscle strength in the elderly, especially in females.
Publisher
Research Square Platform LLC