The association between 8-OHdG levels and diabetic neuropathy patients from sensory functioning and neurological symptoms

Abstract

Abstract Objective This clinical study aims to evaluate the association between the levels of urine 8-hydroxy-2-deoxyguanosine (8-OHdG) and neuropathic symptoms and nervous sensory signs in patients with diabetic peripheral neuropathy (DPN). Methods A total of 81 individuals with DPN participated in this clinical investigation. According to patients’ symptoms, the nerve conduction studies (NCS), the neuropathy symptom scores (NSS) and their neuropathy deficit scores (NDS) category, four symptom clusters were allocated: no symptoms, mild symptoms, moderate symptoms, and severe symptoms. The four neurological function categories were defined as no signs, mild signs, moderate signs and severe signs. We used an enzyme-linked immunosorbent assay kit to measure the levels of urine 8-OHdG. All statistical tests were performed using the Statistical Package for the Social Sciences, version 25.0 (IBM-SPSS, Chicago, IL, USA). Results Based on the results of the ordinary logistic regression, it can be concluded that neuropathic sensory function deficits were not related to neuropathic symptoms in patients with DPN; age was associated with neuropathic function deficits of the left and right feet in DPN patients; and the level of urine 8-OHdG was correlated with neuropathic symptoms in patients with DPN. Conclusions In this clinical study, it can be deduced that neuropathic sensory function was not linked with neuropathic symptoms in diabetic neuropathy patients. We identified that the clinical parameters of age were associated with the development of neuropathic function deficits and that the level of urine 8-OHdG was related to the development of neuropathic symptoms in patients with DPN.