Incidence and risk of pancreatic cancer in patients with acute or chronic pancreatitis: a population-based cohort study

Author:

Park Seon Mee1,Kim Ki Bae2,Han Joung-Ho1,Kim Nayoung3,Kang Tae Uk4,Swan Heather5,Kim Hyun Jung5

Affiliation:

1. Chungbuk National University college of medicine

2. Chungbuk National University Hospital

3. Seoul National University College of Medicine

4. Health & Wellness College, Sungshin Women's University

5. Department of Preventive Medicine, Korea University College of Medicine

Abstract

Abstract We aimed to evaluate the incidence and risk of PC in pancreatitis. We identified patients with acute pancreatitis (AP) (n = 225,811, 50.0%) and chronic pancreatitis (CP) (n = 225,685, 50.0%) from Korean population-based data and matched them with age- and sex-matched controls (n = 4,514,960). We analyzed the incidence and adjusted hazard ratios (aHRs) of PC among patients followed for more than 2 years or 5 years, and assessed risk changes over time in single episode of AP (SAP), recurrent AP (RAP), CP with AP, and CP without AP groups. We also performed subgroup analysis for both sexes. The incidences (per 104 person-years) and risks (aHR) of PC were higher in the RAP (12.69, 5.00) or CP with AP (12.12, 5.74) groups compared to the SAP (2.31, 1.32) or CP without AP (2.28, 1.57) groups. The risks of PC decreased over time, however, the risk of PC remained elevated in the RAP and CP with AP groups for more than 8 years. Females with RAP, SAP, and CP with AP had higher risks of PC than males. The risk of PC is higher and persists for longer duration in patients with RAP and CP with AP compared to those with SAP or CP without AP.

Publisher

Research Square Platform LLC

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