Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery
Author:
Fujita Hiroaki1, Wakiya Taiichi1, Tatara Yota2, Ishido Keinosuke1, Sakamoto Yoshiyuki1, Kimura Norihisa1, Morohashi Hajime1, Miura Takuya1, Muroya Takahiro1, Akasaka Harue1, Yokoyama Hiroshi1, Kanda Taishu1, Kubota Shunsuke1, Ichisawa Aika1, Ogasawara Kenta1, Kuwata Daisuke1, Takahashi Yoshiya1, Nakamura Akie1, Yamazaki Keisuke1, Yamada Takahiro1, Matsuyama Ryo3, Kanou Masanobu3, Yamana Kei3, Itoh Ken2, Hakamada Kenichi1
Affiliation:
1. Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine 2. Department of Stress Response Science, Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine 3. Nutraceutical Group, New Business Development Unit, Teijin Limited
Abstract
Abstract
Nicotinamide adenine dinucleotide (NAD+) plays a pivotal role in numerous cellular functions. Reduced NAD+ levels are postulated to be associated with cancer. As interest in understanding NAD+ dynamics in cancer patients with therapeutic applications in mind grows, there remains a shortage of comprehensive data. This study delves into NAD+ dynamics in patients undergoing surgery for different digestive system cancers. This prospective study enrolled 99 patients with eight different cancers. Fasting blood samples were obtained during the perioperative period. The concentrations of NAD+, nicotinamide mononucleotide (NMN), and nicotinamide riboside were analyzed using tandem mass spectrometry. Initial measurements showed lower NAD+ concentrations in cancer patients compared to previously studied healthy donors. After erythrocyte volume adjustment, NAD+ remained relatively stable after surgery. Meanwhile, NMN decreased the day after surgery and displayed a recovery trend. Interestingly, liver and pancreatic cancer patients exhibited poor postoperative NMN recovery, suggesting a potential cancer type-specific influence on NAD+ metabolism. This study illuminated the behavior of NAD+ in surgically treated cancer patients. We identified which cancer types have particularly low levels and at what point depletion occurs during the perioperative period. These insights suggest the need for personalized NAD+ supplementation strategies, calibrated to individual patient needs and treatment timelines.
Clinical trial registration
jRCT1020210066
Publisher
Research Square Platform LLC
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