The Role and Therapeutic Potential of the TFAP2C-EIF5A Signaling Pathway in Bladder Cancer Development

Abstract

Abstract Bladder cancer is a common malignant tumor, and the molecular mechanisms underlying its onset and progression are unclear. In this study, we analyzed the cellular heterogeneity and subpopulations of bladder cancer patients using single-cell sequencing data, and found that the expression levels of the transcription factor TFAP2C and the translation initiation factor EIF5A were significantly elevated in bladder cancer tissues and positively correlated with cancer mortality. Further in vitro experiments verified that TFAP2C could up-regulate the expression of EIF5A, thereby promoting the proliferation, migration and invasion ability of bladder cancer cells. In addition, we found that inhibition or activation of EIF5A could affect the function of TFAP2C. These results reveal the important role of the TFAP2C-EIF5A signaling pathway in bladder cancer development and provide new targets and strategies for the future treatment of bladder cancer.