The impact of parental consanguineous marriage on the incidence rate, incidence age, and severity of coronary artery disease

Abstract

Abstract Background Consanguineous marriage (CM) 's impact on cardiovascular diseases, including structural congenital heart diseases, has been confirmed. Although CM can affect genetics with oligogenicity and homogeneity, the relationship between CM and coronary artery disease (CAD) has not been conclusively confirmed. Therefore, this study was conducted to determine the relationship between CAD and CM. Methods We conducted a cross-sectional-prospective study from June 2021 to August 2022. Patients undergoing coronary angiography at Tehran Heart Center were included. A questionnaire was designed, including demographic and anthropometric information, past medical history, cardiovascular risk factors, results of previous angiograms, and parental kinship. Finally, 11,986 patients were analyzed regarding the relationship between CAD and CM. Results 69.9% of the patients included in this study were male. The mean age of the patients was 58.9 ± 10.7 years. Out of 11986 patients, 9083 (75.8%) patients had CAD. One thousand five hundred fifteen (12.7%) patients were with parental CM. This study showed that the incidence of CAD in patients with parental CM is 3.2% higher than in patients with parental non-CM (P-value < 0.001). Also, CM reduces the mean age of CAD occurrence independently of other cardiovascular risk factors by 2.4 years [OR -2.4, 95% CI -3.5_-1.8, P-value < 0.001]. Conclusions The incidence of CAD in patients with parental CM is higher than in patients with parental non-CM. The parental CM reduces the age of onset of CAD in their children. Therefore, parental CM should be considered one of the risk factors for CAD.