Survival Benefits of Primary Tumor Surgery in Diverse Cancer Types with Synchronous Bone Metastases: A Retrospective Real-World Analysis Using Propensity Score Matching from a 3P Medicine Perspective

Author:

Shi Bochong1,Xu Peihang1,Xu Lun1,Cheng Mo1,Wang Shuoer1,Liang Chao1,Huang Wending1,Cai Weiluo1,Yan Wangjun1

Affiliation:

1. Fudan University Shanghai Cancer Center

Abstract

Abstract Background: Bone metastasis (BM) is a common occurrence significantly impacting their quality of life and overall survival, and the role of primary site surgery (PTS) is also mentioned. However, the specific diagnostic and treatment model for PTS needs to be elucidated in order to transition from reactive medicine toward a step-by-step approach to predictive, preventive, and personalized medicine (PPPM). This study aims to investigate the potential survival advantages associated with PTS in patients with varying cancer types presenting concurrent BMs. Methods: A comprehensive analysis was conducted on patients exhibiting exclusive BM, encompassing data from the Surveillance, Epidemiology, and End Results (SEER) database spanning 2010 to 2019. Specifically, we focused on BMs originating from multiple cancers, and patients were categorized into PTS group or its absence (No PTS). Employing propensity score matching (PSM), we meticulously compared the overall survival (OS) and cancer-specific survival (CSS) rates between these two cohorts. Additionally, we examined survival outcomes after patients experienced diverse surgical and treatment modalities. Furthermore, we conducted subgroup analysis to explore target populations suitable for PTS. Results: 53,015 patients were encompassed within this study. Breast cancer, renal cell carcinoma, bladder cancer, and lung cancer patients with BM were more inclined to undergo PTS. Across different cancer types, the choice of surgical approach and extent of resection exhibited heterogeneity in survival prognosis. Substantial enhancement in survival was observed in patients presenting early-stage and lower-grade metastases upon undergoing PTS.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3