Maternal stress-induced behavioral changes diminished by maternal exposure to an electromagnetic field (50 Hz, 100 µTesla) in male rat offspring

Author:

Farid-Habibi Mahsa1,Mohaddes Gisou1,Abkhezr Hajar1,Farajdokht Fereshteh1,Heydari Hamed1,Babri Shirin1

Affiliation:

1. Tabriz University of Medical Sciences

Abstract

Abstract Prenatal exposure to stress predisposes offspring to mental health problems in adulthood. However, the underlying mechanisms remain obscure. The prefrontal cortex's (PFC) role is vital in regulating sleep and mood. Cryptochrome type 2 (CRY2), as a magnetoreceptor and an important part of the circadian system, has been linked to depression and anxiety. We aimed to determine CRY2 role in prenatal stress and extremely low-frequency electromagnetic fields (ELF-EMF) on the PFC of rat offspring and its relationship with behavior. Female Wistar rats were exposed to chronic mild stress (CMS) or electromagnetic field (EMF) (50 Hz, 100 μT, 4 h/day) for 21 days before and during pregnancy. Behavioral tests, including the elevated plus maze, open field, and forced swimming test, were conducted on the male offspring at postnatal day (PND) 80, 81, 90. The expressionof CRY2 in the PFC and levels of serum corticosterone (CORT) were also measured. The results showed that maternal stress exposure caused anxiety- and depression-like behaviors in the male offspring, accompanied by decreased prefrontal CRY2 protein expression and increased serum CORT levels. In addition, maternal EMF had no significant effect on CRY2 expression in the male offspring. However, parallel ELF-EMF and stress exposure significantly attenuated anxiety and depression-like behaviors and decreased serum CORT levels.

Publisher

Research Square Platform LLC

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