Disruption of the white matter structural network in patients with hemifacial spasm and changes after microvascular decompression

Author:

Lv Kuan1,Zhang Chuanpeng1,Liu Bing2,Yang Aocai2,Luan Jixin2,Hu Pianpian1,Yao Zeshan3,Liu Jiang4,Ma Guolin4

Affiliation:

1. Peking University China-Japan Friendship School of Clinical Medicine

2. Chinese Academy of Medical Sciences, Peking Union Medical College

3. Jingjinji National center of Technology Innovation

4. China-Japan Friendship Hospital

Abstract

Abstract Hemifacial spasm (HFS) is a syndrome characterized by involuntary contractions of the facial muscles innervated by the ipsilateral facial nerve. Currently, microvascular decompression (MVD) is an effective treatment for HFS. Diffusion tensor imaging (DTI) is a non-invasive advanced magnetic resonance technique that allows us to reconstruct white matter (WM) virtually based on water diffusion direction. This enables us to model the human brain as a complex network using graph theory. In our study, we recruited 32 patients with HFS and 32 healthy controls to analyze and compare the topological organization of whole-brain white matter networks between the groups. We also explored the potential relationships between altered topological properties and clinical scale scores. Compared to HC group, the white matter network was disrupted in both preoperative and postoperative groups of HFS patients, mainly located in the somatomotor network, limbic network and default network. There was no significant difference between the preoperative and postoperative groups. There was a correlation between the altered topological properties and clinical scale scores in the postoperative group of patients. Our findings indicate that in HFS, the white matter structural network was disrupted before and after MVD, and these alterations were correlated with the clinical symptoms. It is suggested that these which may be some potential neuroimaging biomarkers for HFS.

Publisher

Research Square Platform LLC

全球学者库

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2023 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3