The comparative analysis of the clinicopathologic and CT features of hepatitis B virus- positive and negative intrahepatic cholangiocarcinoma patients with different pathological degree differentiation

Abstract

Abstract Background hepatitis B is a risk factor for the development of intrahepatic cholangiocarcinoma. The prognosis of HBV-related ICC remains to be further investigated. AimsTo investigate the clinical, pathological and imaging features of intrahepatic cholangiocarcinoma of hepatitis B virus-positive and -negative patients. MethodsData from January 31, 2012 to December 31, 2019 of 138 patients were retrospectively analyzed. The patients were divided into hepatitis B virus-positive group (group A[n=66]) and virus-negative group (group B[n=72]), and the patients were divided into well-to-moderately differentiated group and poorly differentiated group according to pathological differentiation degree. The differences in clinical, imaging characteristics and the progression-free survival between groups were statistically analyzed. Results There were significant differences in gender, age, HBs antibody, HBc antibody, CA125 and AFP between the two groups (P<0.05); tumor distribution site, maximum diameter, plain scan density, blunting of the inferior hepatic angle, peritumoral bile duct dilatation, vascular encasement invasion, intrahepatic bile duct dilatation and abdominal lymphadenopathy between the two groups (P<0.05); There were statistical differences in tumor plain scan density and signs of vascular encasement and invasion between the two groups with well-to-moderately differentiated tumors (P<0.05); there were statistical differences in tumor plain scan density, signs of vascular encasement and lymphadenopathy between the two groups with poorly differentiated tumors (P<0.05). There was no statistical difference in postoperative PFS between the two groups (P>0.05). Conclusion The clinical and imaging features of ICC of hepatitis B virus-positive and -negative patients are different, and there is little difference in postoperative disease-free survival time.