Affiliation:
1. Institute for Developmental Research, Aichi Developmental Disability Center
Abstract
Abstract
Prepulse inhibition (PPI) refers to the phenomenon in which a weak sensory input, that by itself does not reliably induce a startle reflex, suppresses the startle reflex induced by a subsequent strong sensory stimulus. A major challenge in studying PPI is the incomplete understanding of the startle reflex pathway as well as inhibition mechanisms. Here we focused on short-latency PPI of the trigeminal blink reflex R1 signal with an oligosynaptic reflex arc to clarify whether the PPI mechanism involves GABA-A equivalent inhibition. The reflex was elicited by electrical stimulation of the supraorbital nerve, and was recorded from the ipsilateral lower eyelid using an accelerometer. The stimulus intensity was 1.5 times the R1 threshold for the test stimulus and 0.9 times for the prepulse. The prepulse–test interval (PTI) was 5–150 ms. Results yielded two distinct inhibitions with different time scales; early inhibition peaking at 40-ms PTI or earlier, and a later one after 80-ms PTIs, which corresponds well to the common early and late components of inhibitory post synaptic potentials. There is clinical benefit to understanding the relative behavior of these two components in inhibitory function related diseases.
Publisher
Research Square Platform LLC
Reference28 articles.
1. Diversity of inhibitory neurotransmission through GABA(A) receptors;Mody I;Trends Neurosci.,2004
2. Interneuron dysfunction in psychiatric disorders;Marín O;Nat Rev Neurosci,2012
3. GABAergic signaling as therapeutic target for autism spectrum disorders;Cellot G;Front Pediatr.,2014
4. Neurophysiological evidence for a defect in neuronal mechanisms involved in sensory gating in schizophrenia;Adler LE;Biol Psychiatry.,1982
5. Mechanisms of Long-Latency Paired Pulse Suppression: MEG Study;Takeuchi N;Brain Topogr.,2022