Advancements in the Research of Modified Hydroxyapatite Materials for Bone Repair : a Scoping Review

Abstract

Abstract Modified hydroxyapatite (mHA) materials have shown efficacy in bone defect repair, exhibiting excellent properties such as biocompatibility, mechanical performance, antibacterial activity, and degradability. This article aims to consolidate existing research on the various aspects of mHA materials, discussing their superior performance and the fundamental principles of osteoinduction. Additionally, it explores the potential of these materials to facilitate the exploration of novel bone repair materials in the future. The primary objective of this study is to provide new insights into optimizing the functionality and structure of bone repair materials, as well as enhancing their biocompatibility, mechanical properties, antibacterial capabilities, and degradability. A systematic search was conducted in PubMed and Web of Science databases for relevant articles on modified hydroxyapatite materials. A total of 601 articles were retrieved, 461 articles with poor correlation with the purpose of the study, obsolete content, repetition and stage of the same author were excluded, and 140 articles that met the criteria were reviewed. The critical analysis and synthesis were based on the examination of in vitro and in vivo experimental results, and theoretical foundations of mHA materials. The discussion section addresses the current challenges and identifies future directions in this field.