Affiliation:
1. Graduate School of Dalian Medical University, Dalian Medical University
2. Changzhou No.2 People's Hospital
Abstract
Abstract
tRNA-derived RNA fragments (tRFS) are 14-38nt long non-coding single-stranded RNAs that play an important role in gene regulation. In this study, we investigated the expression of tRF-Pro-CGG in human pancreatic cancer (PC) and its role in the proliferation, cloning, metastasis, invasion and apoptosis of PC cell lines. We will investigate the expression levels of tRF-Pro-CGG in PC tissues and cells. In PC tissue, tRF-Pro-CGG RNA levels were lower than in normal tissue, and in PC cell lines, tRF-Pro-CGG RNA levels were lower. In PC cells, promotion of tRF-Pro-CGG inhibits cell proliferation, replication, migration, and invasion, and promotes apoptosis. CSF1 was also inhibited by tRF-Pro-CGG. tRF-Pro-CGG may be involved in the regulation of CSF1 and may become a new diagnostic marker or therapeutic target for PC.
Publisher
Research Square Platform LLC