Impact of caudate lobe resection on overall survival and liver disease-free survival in colorectal liver metastases: A pilot study

Abstract

BACKGROUND This study aimed to evaluate the management of colorectal liver metastases (CRLM) and the role of anatomical resections, with particular reference to the caudate lobe. METHODS We obtained all patient data from the Preoperative CT and Survival Data for Patients Undergoing Resection of Colorectal Liver Metastases dataset. Patients who underwent total caudate lobe resection without radiological evidence of metastases were analyzed. To investigate the net effect of caudate lobe resection, propensity score matching (PSM) was applied to most other parameters. The Kaplan-Meier and log-rank tests were used to calculate overall survival (OS) and liver disease-free survival (liver-DFS) and to investigate differences between groups. RESULTS Patients who underwent total caudate resection had better results in terms of overall survival in the whole data set and after PSM (respectively, p < 0.001 HR: 0.43, 95%CI:0.26–0.72 p:0.024, HR: 0.65 95%CI:0.59–0.79).Patients who underwent total caudate resection had better results in terms of liver-DFS in the whole data set set and after PSM (respectively, p = 0.014, HR = 0.46, 95%CI: 0.24–0.85, p = 0.026 HR = 0.5, 95%CI: 0.37–0.79) CONCLUSİONS We believe that the addition of total caudate lobe resection to resection may contribute to both OS and liver DFS.